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Genomics

The MIT ROSMAP Single-Nucleus Multiomics Study (MITROSMAPMultiomics)

The MIT ROSMAP Single-Nucleus Multiomics Study provides single-nucleus transcriptomic and chromatin accessibility data generated from postmortem brain tissue from participants in the Religious Orders Study and Rush Memory and Aging Project (ROSMAP). The study includes single-nucleus RNA sequencing, single-nucleus ATAC sequencing, and paired multiome data from 427 prefrontal cortex samples, as well as single-nucleus RNA sequencing data from multiple brain regions. These data support investigation of cell-type-specific molecular changes, cellular vulnerability, cognitive resilience, and Alzheimer's disease progression.

Listed for discovery. Access is provided by the original publisher under its terms.

Data coverage

The MIT ROSMAP Single-Nucleus Multiomics Study provides single-nucleus transcriptomic and chromatin accessibility data generated from postmortem brain tissue from participants in the Religious Orders Study and Rush Memory and Aging Project (ROSMAP). The study includes single-nucleus RNA sequencing, single-nucleus ATAC sequencing, and paired multiome data from 427 prefrontal cortex samples, as well as single-nucleus RNA sequencing data from multiple brain regions. These data support investigation of cell-type-specific molecular changes, cellular vulnerability, cognitive resilience, and Alzheimer's disease progression.

Access & permitted use

Review the publisher’s documentation for availability, eligibility and permitted uses, including commercial analysis, model training and redistribution.

https://adknowledgeportal.synapse.org/Explore/Studies/DetailsPage/StudyDetails?Study=syn52293417Acknowledgement

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